Nanoparticles engineered with Rituximab and loaded with Nutlin-3 show promising therapeutic activity in B leukemic xenografts Running title: Rituximab plus Nutlin-3 loaded nanoparticles
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1 Nanoparticles engineered with Rituximab and loaded with Nutlin-3 show promising therapeutic activity in B leukemic xenografts Running title: Rituximab plus Nutlin-3 loaded nanoparticles Rebecca Voltan, Paola Secchiero, Barbara Ruozi, Flavio Forni, Chiara Agostinis, Lorenzo Caruso, Maria Angela Vandelli, Giorgio Zauli The first two Authors equally contributed to this work. Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
منابع مشابه
Nanoparticles engineered with rituximab and loaded with Nutlin-3 show promising therapeutic activity in B-leukemic xenografts.
PURPOSE Because the nongenotoxic inhibitor of the p53/MDM2 interactions Nutlin-3 has shown promising in vitro therapeutic activity against a variety of p53(wild-type) cancer cells, in this study we evaluated an innovative strategy able to specifically target Nutlin-3 toward CD20(+) malignant cells. EXPERIMENTAL DESIGN The cytotoxic effects of Nutlin-3 encapsulated into poly(lactide-co-glycoli...
متن کاملCancer Therapy: Preclinical Nanoparticles Engineered with Rituximab and Loaded with Nutlin-3 Show Promising Therapeutic Activity in B-Leukemic Xenografts
Purpose: Because the nongenotoxic inhibitor of the p53/MDM2 interactions Nutlin-3 has shown promising in vitro therapeutic activity against a variety of p53 cancer cells, in this study we evaluated an innovative strategy able to specifically target Nutlin-3 toward CD20þ malignant cells. Experimental Design: The cytotoxic effects of Nutlin-3 encapsulated into poly(lactide-co-glycolide) nanoparti...
متن کاملNutlin-3 upregulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feed-back anti-apoptotic mechanism Running title: Nutlin-3 upregulates Notch1 expression
The small molecule inhibitor of the MDM2/p53 interaction Nutlin-3 significantly up-regulated the steady-state mRNA and protein levels of Notch1 in p53 wild-type (OCI, SKW6.4) but not in p53 deleted (HL-60) or p53 mutated (BJAB) leukemic cell lines. A direct demonstration that Notch1 was a transcriptional target of p53 in leukemic cells was obtained in experiments carried out with siRNA for p53....
متن کاملNutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.
The small molecule inhibitor of the MDM2/p53 interaction Nutlin-3 significantly up-regulated the steady-state mRNA and protein levels of Notch1 in TP53(wild-type) (OCI, SKW6.4) but not in TP53(deleted) (HL-60) or TP53(mutated) (BJAB) leukemic cell lines. A direct demonstration that NOTCH1 was a transcriptional target of p53 in leukemic cells was obtained in experiments carried out with siRNA fo...
متن کاملLYMPHOID NEOPLASIA Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
The small molecule inhibitor of the MDM2/ p53 interaction Nutlin-3 significantly upregulated the steady-state mRNA and protein levels of Notch1 in TP53wild-type (OCI, SKW6.4) but not in TP53deleted (HL-60) or TP53mutated (BJAB) leukemic cell lines. A direct demonstration that NOTCH1 was a transcriptional target of p53 in leukemic cells was obtained in experiments carried out with siRNA for p53....
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تاریخ انتشار 2013